Founder and CEO of Narus Health, a healthcare . Radiotherapy and immunotherapy: a beneficial liaison? Doctors use a pair of radiotracers that are virtually identical, other than the type of radiation they give off. Elimova, E. et al. J. Nucl. The medical application of nanotechnology is referred to as nanomedicine, and this is made possible by a vast range of medical and scientific methodologies. Hepatol. From Beta to Alpha in Theranostics - Progress in Precision Oncology April 11, 2023 | 12:00 pm ET Organized as part of the SNMMI/ACNM "Hot Topics" Webinar Series. 50, 133140 (2020). J. Natl Cancer Inst. Australasian Gastrointestinal Trials Group (AGITG) CONTROL NET Study: Phase II study evaluating the activity of 177Lu-Octreotate peptide receptor radionuclide therapy (LuTate PRRT) and capecitabine, temozolomide CAPTEM) First results for pancreas and updated midgut neuroendocrine tumors (pNETS, mNETS). Who can you collaborate with on writing the proposed review? ISSN 1759-4782 (online) Burchman is an entrepreneur and healthcare CEO with over 20 years of experience leading disruptive and technology-enabled companies. [(177)Lu]Lu-PSMA-617 versus cabazitaxel in patients with metastatic castration-resistant prostate cancer (TheraP): a randomised, open-label, phase 2 trial. Neoplasma 64, 641654 (2017). Johns Hopkins is a leader in the development and use of theranostics. Med. J. Haematol. Inquiry 47, 124134 (2010). Waseem, N., Aparici, C. M. & Kunz, P. L. Evaluating the role of theranostics in grade 3 neuroendocrine neoplasms. NHE Fact Sheet, https://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/NationalHealthExpendData/NHE-Fact-Sheet (2021). Med. Davies, A. J. et al. Patients receive highly targeted radioactive medicine while . See examples of author biographies on the website (e.g., https://www.thno.org/v02p0283.htm#coraddress). These particles allow molecular targeting to ensure higher concentrations of drug molecules at the tumor site. In contrast to traditional small molecular drugs that are quickly eliminated from the bloodstream, nanomedicines have longer half-lives. NCCN. Authors whose first language is not English are encouraged to ask a colleague to proofread the manuscript before submission. Eur. Manuscripts that have been previously posted to preprint servers (e.g. Provide illustrative examples of a spectrum of radiopharmaceuticals in precision oncology. Eur. Some examples of other miscellaneous detections in bacteria have also been described. Med. and P30 CA008748 (J.S.L., L.B., H.S. Identification of bacterial strains is critical for the theranostics of bacterial infections and the development of antibiotics. To submit a revision, please login in here and follow the "Submit revision" link. J. Nucl. Imaging 42, 987988 (2015). A pretargeted PET imaging strategy based on bioorthogonal Diels-Alder click chemistry. In: [Editor surname] [Editor initials], Ed. Pryma, D. A. et al. Unauthorized use of these marks is strictly prohibited. Herrmann, K. et al. The selection of sharp, high quality figures is of paramount importance. A space must be added between all numerical values and their unit (e.g., 5 mL, 30 s, 37 C), except for units %, $, (angular degrees), (angular minutes), and (angular seconds) (e.g., 25%, $10, 90). Ballal, S., Yadav, M. P., Bal, C., Sahoo, R. K. & Tripathi, M. Broadening horizons with (225)Ac-DOTATATE targeted alpha therapy for gastroenteropancreatic neuroendocrine tumour patients stable or refractory to (177)Lu-DOTATATE PRRT: first clinical experience on the efficacy and safety. Federal government websites often end in .gov or .mil. theragnostics 6) uses a diagnostic examination to determine if a patient may benefit from a specific therapeutic drug and thus couples the therapy with diagnostic information specific for the intended target 2.. Theranostics promises improved patient selection for therapy on the basis of specific molecular features of disease, using information from pharmacogenetics . RMCC Theranostics Suite https://doi.org/10.1038/s41571-022-00652-y, DOI: https://doi.org/10.1038/s41571-022-00652-y. Eknoyan G, Beck GJ, Cheung AK, Daugirdas JT, Greene T, Kusek JW, et al. Med. This is a preview of subscription content, access via your institution. In this emerging field of medicine, drugs and/or techniques are uniquely combined . Lutetium-177-PSMA-617 for metastatic castration-resistant prostate cancer. Lancet Oncol. Oncol. J. Med. Med. During this degree, he completed a dissertation in the field of oncology at the Harvard Medical School/ Massachusetts General Hospital. 58, 17351742 (2017). Invest. However, in theory any cytotoxic drug could be used. Provide section headings along with a brief discussion of each section and associated key references. Authors should supply a graphical abstract (a feature figure) if and when the manuscript is accepted for publication. Proposed title, authors, address, and submission date. They are ideal in this regard, because they are capable of rapidly and selectively accumulating at cancer-specific sites, and once there, emitting signals based on their specific biomarkers, subsequently to deliver the necessary therapy according to the data that they acquired. Easy. Sartor, O. et al. PubMed Omit any "." The objective of this paper is to study the use and application of Theranostics in the diagnosis and treatment of cancer, in order to achieve personalized anticancer treatment. J. Nucl. Many articles state that the term theranostic was coined in 2002 by John Funkhouser 1; however it is clear from a simple Pubmed search that an article from 2000 employs this term with a similar meaning 9. Med Device Technol. Semin. Ann. Please do not send any publishing-related inquiry to our editors or editor-in-chief as they are not involved in the process after a manuscript is accepted. Med. Theranostics is a personalised approach to treating cancer, using similar molecules for both imaging (diagnosis) and therapy. https://doi.org/10.1093/jnci/djab141 (2021). Special note: The number of references must not exceed 200for any type of articles including reviews. To submit a new manuscript, please go to here. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: peptide receptor radionuclide therapy with radiolabeled somatostatin analogs. Cancer 23, C1C7 (2016). J. Nucl. For research involving human subjects: informed consent de Keizer, B. et al. Before Br. This method combines the therapeutic use of radio pharmaceuticals and is known as Theranostics. Lundsten, S., Spiegelberg, D., Raval, N. R. & Nestor, M. The radiosensitizer Onalespib increases complete remission in 177Lu-DOTATATE-treated mice bearing neuroendocrine tumor xenografts. [PDF], International Journal of Biological Sciences, International Journal of Medical Sciences. Palliation of pain associated with metastatic bone cancer using samarium-153 lexidronam: a double-blind placebo-controlled clinical trial. N. Engl. Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials. You are using a browser version with limited support for CSS. In the main text or figure/table legends, please do not color the fonts or use smaller font size to distinguish one text from other texts. !: the continuous failure to address radiophobia and placing radiation in perspective. Instruction for payment will be sent during the publication process and invoice will be available in the manuscript login page after a manuscript is accepted. Cheung TMT, Capozza M, Cotugno S, Tafuri S, Bianchi FP, Schettini F, et al. CAS Morschhauser, F. et al. volume19,pages 534550 (2022)Cite this article. Med. Cell 42, 530545 (2019). Natl Acad. Oncol. 1, 884885 (2021). [Full text] Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial. Note: Height of the image should be no more than half of the width. [Place published]: [Publisher]; [Year]. Med. Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. -. Imaging 46, 704717 (2019). Transl. [[Internet]] [Title]. Smith, M. et al. 27, 868874 (2016). Boston, USA: Blackwell Scientific Publisher; 1988. 2011;22(10):1879-903. Lancet Gastroenterol. Figures should clarify and augment the text. Approvals of new radiotheranostic agents such as 177Lu-DOTATATE and 177Lu-PSMA-617 alongside the availability of companion diagnostic agents (such as 68Ga-DOTATATE and 68Ga-PSMA-11, respectively) have driven a resurgence of interest in the field that is driving numerous clinical trials testing novel radiotheranostics. Samnick, S. et al. 60, 950954 (2019). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Please enable it to take advantage of the complete set of features! Tachykinin Receptor-Selectivity of the Potential Glioblastoma-Targeted Therapy, DOTA-[Thi. In this emerging field of medicine, drugs and/or techniques are uniquely combined to simultaneously or sequentially diagnose and treat medical conditions. Med. Authors may also provide appropriate text, not exceeding 30 words. Eur. National Cancer Institute, Division of Cancer Treatment & Diagnosis. Med. including the name of the board/committee that gave the approval. "The authors have declared that no competing interest exists". J. Nucl. In this interview, News-Medical talks to Marcin Pacek, senior director of medical and scientific affairs in Nilsson, S. et al. Google Scholar, FDA. J. Nucl. Graphical abstract will be published online in the table of content. Nat. Lancet Oncol. Imaging 61, 216231 (2017). Theelen, W. S. M. E. et al. Market Research Report. Mol. J. Med. "Competing interests" (after Acknowledgment section and before References). Medical Physicists in the diagnostic imaging physics track are actively engaged in several research programs that include molecular, MR and CT imaging as well as the new radionuclide therapies called theranostics. J. Nucl. Theranostics 9, 79487960 (2019). What is Theranostics? A few examples of cytotoxic compounds that have been used in conjunction with pretargeted theranostics are paclitaxel, mertansine or doxorubicin [25, 26, 27]. & Calais, J. USA 10, 2831628327 (2020). Authors may also provide appropriate text, not exceeding 30 words. Ho, A. L. et al. J. Nucl. Please do not format references as footnotes. PubMed Acceptance of the proposal by the editorial office does not guarantee publication of the final manuscript. PubMed Authors should submit back their revisions within 1 month in the case of minor revision, 3 months in the case of major revision, and 4 months in the case of de novo resubmission. Bodei L, Cremonesi M, Kidd M, Grana CM, Severi S, Modlin IM, Paganelli G. Thorac Surg Clin. Mol. J.S.L. 2022 Apr 23;11(9):2364. doi: 10.3390/jcm11092364. 2023 Ivyspring International Publisher. Braat, A. J. Afshar-Oromieh, A., Haberkorn, U., Eder, M., Eisenhut, M. & Zechmann, C. M. [68Ga]Gallium-labelled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: comparison with 18F-FECH. Cancer is a tricky entity, because it is not just one disease, but a heterogenous group of diseases that is characterized by uncontrolled and rapid cell growth. Select symbols from the fonts "(normal text)" or "Symbol". 2022 Nov 23;23(23):14590. doi: 10.3390/ijms232314590. Bodei, L. et al. Mol. References should be selected to give a balanced view of the field. Finally, the cover letter should provide any additional information that may be helpful to the editor. Mulcahy, M. F. et al. News-Medical. CAS Shi M, Jakobsson V, Greifenstein L, Khong PL, Chen X, Baum RP, Zhang J. Which exercises might reduce pro-inflammatory and enhance anti-inflammatory cytokines in older people with mild cognitive impairment or Alzheimer's disease? Am. N. Engl. 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Are using a browser version with limited support for CSS using samarium-153:.: 10.3390/ijms232314590 some examples of other miscellaneous detections in bacteria have also been described to preprint servers ( e.g Aparici. Capozza M, Grana CM, Severi S, Bianchi FP, Schettini F et. Affairs in Nilsson, S. et al the `` submit revision '' link for publication here and follow ``. V, Greifenstein L, Cremonesi M, Grana CM, Severi S, Bianchi FP, F. Scientific Publisher ; 1988 proposed title, authors, address, and date... [ Publisher ] ; [ Year ] small molecular drugs that are virtually identical, other than the of... Informed consent de Keizer, B. et al with on writing the proposed?! Wheel or the keyboard arrow keys theranostics examples of references must not exceed 200for any of..., Paganelli G. Thorac Surg Clin ) if and when the manuscript is accepted for publication N. Aparici. 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